The Rabbit Anti-OPA1L/WBP1L Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Rabbit Anti-OPA1L/WBP1L Antibody has been validated for the following applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Immunohistochemistry - fixed.
Description
WW domain binding protein 1-like (WBP1L), also known as outcome predictor of acute leukaemia 1 (OPAL1), is a transmembrane adaptor protein, WBP1L protein has a very short extracellular/luminal part followed by a single transmembrane domain and a larger cytoplasmic tail. Although relatively short, the extracellular/luminal part presumably forms a small compact domain held together by disulphide bridges formed among cysteines in the C*C*CC*CC motif. The cytoplasmic part of WBP1L contains several potential interaction motifs corresponding to the consensus sequence of WW domain binding motifs L-P-X-Y or P-P-X-Y. WBP1L expression correlates with ETV6-RUNX1 (t(12;21) (p13;q22)) translocation and favourable prognosis in childhood leukaemia. It has a broad expression pattern in haematopoietic and non-haematopoietic cells